|Catalog No||Formulation||Size||Price (USD)|
|4821-RBM2-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|4821-RBM2-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|4821-RBM2-P2||Purified Ab with BSA and Azide at 200ug/ml||200 ug||549.00|
|4821-RBM2-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|4821-RBM2-P2ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||200 ug||579.00|
|Human Entrez Gene ID||4821|
|Human Gene Symbol||NKX2-2|
|Human Chromosome Location||20p11.22|
|Synonyms||Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman|
|Immunogen||Recombinant human NKX2.2 protein fragment (exact sequence is proprietary)|
|Host / Ig Isotype||Rabbit / IgG, kappa|
|Mol. Weight of Antigen||40-50kDa|
|Species Reactivity||Human. Others not known.|
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Flow Cytometry (0.5-1ug/million cells)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Pancreas or Ewing s sarcoma
200ug/ml of Ab purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.