|Catalog No||Formulation||Size||Price (USD)|
|5133-RBM4-P0||Purified Ab with BSA and Azide at 200ug/ml||20 ug||199.00|
|5133-RBM4-P1||Purified Ab with BSA and Azide at 200ug/ml||100 ug||379.00|
|5133-RBM4-P2||Purified Ab with BSA and Azide at 200ug/ml||200 ug||549.00|
|5133-RBM4-P1ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||100 ug||399.00|
|5133-RBM4-P2ABX||Purified Ab WITHOUT BSA and Azide at 1.0mg/ml||200 ug||579.00|
|Human Entrez Gene ID||5133|
|Human Gene Symbol||PDCD1|
|Human Chromosome Location||2q37.3|
|Synonyms||CD279; hPD-1; hSLE1; PD1; PDCD1; Programmed Cell Death Protein 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2|
|Immunogen||Human recombinant PDCD1 protein fragment (exact sequence is proprietary)|
|Host / Ig Isotype||Rabbit / IgG|
|Mol. Weight of Antigen||55kDa|
|Cellular Localization||Cell Surface & Cytoplasmic|
|Species Reactivity||Human. Others not known.|
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
Flow Cytometry (0.5-1ug/million cells)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
TY cells or Tonsil.
200ug/ml of Ab purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
This antibody is available for research use only and is not approved for use in diagnosis.
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.