Free Shipping in the U.S. for orders over $1000.  Shop Now>>

Printable Datasheet

Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy) Antibody [DMD/3677]

In Stock
Catalog Number Formulation Size Price
1756-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1756-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1756-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human skeletal muscle stained with Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3677).

Formalin-fixed, paraffin-embedded human skeletal muscle stained with Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3677).

SDS-PAGE Analysis of Purified Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3677). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3677). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human skeletal muscle stained with Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3677).

Formalin-fixed, paraffin-embedded human skeletal muscle stained with Dystrophin Monospecific Mouse Monoclonal Antibody (DMD/3677).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Postsynaptic cell membrane, Sarcolemma, Synapse
Gene Name
DMD
Positive Control
Human skeletal muscle and heart muscle tissues (IHC).
Immunogen
A recombinant fragment (around aa 114-263) of human DMD protein (exact sequence is proprietary)
Alternate Names
Dystrophin, BMD; CMD3B; Duchenne muscular dystrophy (DMD); Dystrophin; Muscular dystrophy Duchenne and Becker types

Database Links

Entrez Gene ID
1756
SwissProt
P11532

Additional Information

Clone
DMD/3677
Chromosome Location
Xp21.2
Mol. Weight of Antigen
427kDa

Related Antibodies

View All DMD Antibodies

Functions

  • Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.

Key References

  • BlakeDJ, et al. (2002)Function and genetics of dystrophin and dystrophin related proteins in muscle.Physiol Rev82:291 329.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Reviews

There are no reviews yet.

Be the first to review “Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy) Antibody”

Your email address will not be published. Required fields are marked *

PARTNERSHIP OPPORTUNITIES

NeoBiotechnologies holds Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK
Call Us Now: 1-866-2-NEOBIO (1-866-263-6246)
NeoBiotechnologies Logo
Company Info
Antibodies
Antibody Validation
Research Areas
Resources
Newsletter Signup Updates & Sales