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Formalin-fixed, paraffin-embedded human pancreas stained with Interleukin-1 alpha (IL-1A) Mouse Monoclonal Antibody (IL1A/3982).
Formalin-fixed, paraffin-embedded human colon carcinoma stained with Interleukin-1 alpha (IL-1A) Mouse Monoclonal Antibody (IL1A/3982).
Analysis of Protein Array containing >19,000 full-length human proteins using Interleukin-1 alpha (IL-1A) Mouse Monoclonal Antibody (IL1A/3982). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Two forms of interleukin-1, designated IL-1伪and IL-1尾, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1伪 and IL-1尾 bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1尾 for production of the anti-pathogen IFN-纬. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.
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