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LMO2 (B-Cell Marker) Antibody [LMO2/1972]

In Stock
Catalog Number Formulation Size Price
4005-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4005-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4005-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human follicular lymphoma stained with LMO2 Mouse Monoclonal Antibody (LMO2/1972).

Formalin-fixed, paraffin-embedded human follicular lymphoma stained with LMO2 Mouse Monoclonal Antibody (LMO2/1972).

Formalin-fixed, paraffin-embedded human pancreas stained with LMO2 Mouse Monoclonal Antibody (LMO2/1972).

Formalin-fixed, paraffin-embedded human pancreas stained with LMO2 Mouse Monoclonal Antibody (LMO2/1972).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma.The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin.LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkin s and Burkitt s lymphomas.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Nuclear Marker, Stem Cell Differentiation, Transcription Factors
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Nucleus
Gene Name
LMO2
Positive Control
K562, pancreas or Hodgkin s lymphoma, Ramos or Raji cells.Placenta
Immunogen
Recombinant human LMO2 protein fragment (around aa 23-140) (exact sequence is proprietary)
Alternate Names
Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, T-cell translocation protein 2, Cysteine-rich protein TTG-2; LIM domain only protein 2; LMO-2; RBTN L1; RBTN2;Rhombotinlike 1; Rhombotin-2 (RHOM2); T-cell translocation protein 2; TTG2

Database Links

Entrez Gene ID
4005
SwissProt
P25791

Additional Information

Clone
LMO2/1972
Chromosome Location
11p13
Mol. Weight of Antigen
24kDa

Related Antibodies

View All LMO2 Antibodies

Functions

  • Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Key References

  • Younes, SF et al. Am J Clin Pathol. 2011 May;135(5):697-708.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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