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BARX1 (Prognostic Biomarker in Hepatocellular Carcinoma) Antibody [BARX1/2759]

In Stock
Catalog Number Formulation Size Price
56033-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
56033-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
56033-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
BARX1 (Prognostic Biomarker in Hepatocellular Carcinoma) Antibody

Formalin-fixed, paraffin-embedded human Pancreas stained with BARX1 Mouse Monoclonal Antibody (BARX1/2759).

BARX1 (Prognostic Biomarker in Hepatocellular Carcinoma) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Pancreas stained with BARX1 Mouse Monoclonal Antibody (BARX1/2759).

BARX1 (Prognostic Biomarker in Hepatocellular Carcinoma) Antibody - Image 3

SDS-PAGE Analysis of Purified BARX1 Mouse Monoclonal Antibody (BARX1/2759). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

BarX1 is a member of the Bar subclass of homeobox transcription factors. Studies of the Mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. The protein may also be associated with differentiation of stomach epithelia. Down-regulation of Barx1 promotes HCC migration, invasion and metastasis, whereas up-regulation of Barx1 inhibits HCC migration, invasion and metastasis. The loss of Barx1 expression represents a prognostic biomarker in human HCC.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Nuclear Marker
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Nucleus
Gene Name
BARX1
Positive Control
HepG2 cell lysate. Pancreas.
Immunogen
Recombinant fragment of human BARX1 protein (around aa 155-254) (exact sequence is proprietary)
Alternate Names
Homeobox protein BarH-like 1, BarH like homeobox 1; BarX 1; BARX homeobox 1; Homeobox protein BarH like 1

Database Links

Entrez Gene ID
56033
SwissProt
Q9HBU1

Additional Information

Clone
BARX1/2759
Chromosome Location
9q22.32
Mol. Weight of Antigen
24kDa

Related Antibodies

View All BARX1 Antibodies

Functions

  • Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter

Key References

  • Wang, G., et al. Oncotarget. 2017 Sep 22; 8(42): 71867-71880.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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