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CD282 (Toll-Like Receptor 2) Antibody [TLR2/221]

In Stock
Catalog Number Formulation Size Price
7097-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7097-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7097-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified CD282 Mouse Monoclonal antibody (TLR2/221). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified CD282 Mouse Monoclonal antibody (TLR2/221). Confirmation of Purity and Integrity of Antibody.

Summary

This MAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Functional Studies
Species Reactivity
Dog, Human, Monkey
Research Areas
Cardiovascular, Hypoxia, Immuno Oncology, Immunology, Colon Cancer, Complement System, Infectious Disease, Mitochondria Marker, Nuclear Marker
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Cytoplasmic vesicle, Membrane, Membrane raft, Phagosome membrane
Gene Name
TLR2
Positive Control
macrophage and monocytes in tonsil., Normal human peripheral blood cells. Dendritic cells
Immunogen
Recombinant full-length human TLR2 protein.
Alternate Names
Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282; Toll-like receptor 2 (TLR2); Toll/interleukin-1 receptor-like protein 4 (TIL4)

Database Links

Entrez Gene ID
7097
SwissProt
O60603

Additional Information

Clone
TLR2/221
Chromosome Location
4q32
Mol. Weight of Antigen
~90kDa

Related Antibodies

View All TLR2 Antibodies

Functions

  • Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity).

Key References

  • Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, Finberg RW, Carroll JD, Espevik T, Ingalls RR, Radolf JD, Golenbock DT. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem. 1999 Nov 19;274(47):33419-25.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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