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ASRGL1 (Asparaginase Like 1) Antibody [CRASH/1289]

In Stock
Catalog Number Formulation Size Price
80150-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
80150-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
80150-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
ASRGL1 (Asparaginase Like 1) Antibody

Formalin-fixed, paraffin-embedded human Fallopian Tube stained with ASRGL1 Mouse Monoclonal Antibody (CRASH/1289).

ASRGL1 (Asparaginase Like 1) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Endometrium stained with ASRGL1 Mouse Monoclonal Antibody (CRASH/1289).

ASRGL1 (Asparaginase Like 1) Antibody - Image 3

Formalin-fixed, paraffin-embedded human Uterus stained with ASRGL1 Mouse Monoclonal Antibody (CRASH/1289).

ASRGL1 (Asparaginase Like 1) Antibody - Image 4

SDS-PAGE Analysis of Purified ASRGL1 Mouse Monoclonal Antibody (CRASH/1289). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

ASRGL1 (Asparaginase-like protein 1), also known as CRASH, is a 308 amino acid protein belonging to the Ntn-hydrolase family. Asparaginases utilize asparagine as a substrate to produce aspartic acid and ammonia. ASRGL1 has been identified as a autoantigenic protein that is present in the mid-piece of sperm after obstruction of the male reproductive tract. ASRGL1 is expressed highly in testis, but is also expressed in brain, kidney and gastrointestinal tissues. High levels of ASRGL1 have also been identified in ovarian, uterine and mammary tumors in comparison with normal tissues of the same origin.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm
Gene Name
ASRGL1
Positive Control
Endometrium, HeLa cells. Fallopian Tube, Uterus or Cervix.
Immunogen
Recombinant human ASRGL1 fragment
Alternate Names
Isoaspartyl peptidase/L-asparaginase, Asparaginase-like protein 1, Beta-aspartyl-peptidase, Isoaspartyl dipeptidase, L-asparagine amidohydrolase, ALP1; ASGL1; Asparaginase like 1; ASRGL1; beta-aspartyl-peptidase; CRASH; isoaspartyl dipeptidase; isoaspartyl peptidase/L-asparaginase; L asparaginase; L asparagine amidohydrolase

Database Links

Entrez Gene ID
80150
SwissProt
Q7L266

Additional Information

Clone
CRASH/1289
Chromosome Location
11q12.3
Mol. Weight of Antigen
17-25kDa

Related Antibodies

View All ASRGL1 Antibodies

Functions

  • Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Key References

  • Evtimova, V. et al. 2004. Int. J. Oncol. 24: 33-41.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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