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CD5 (Mantle Cell Lymphoma Marker) Antibody [B-B8]

In Stock
Catalog Number Formulation Size Price
921-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
921-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
921-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

Recognizes a 67kDa transmembrane protein which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Note that this MAb is not suitable for frozen tissues.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
CD5
Positive Control
293T, Ramos or MOLT-4 cells. Tonsil.
Immunogen
T cells activated with PHA
Alternate Names
T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

Database Links

Entrez Gene ID
921
SwissProt

Additional Information

Clone
B-B8
Chromosome Location
11q12.2
Mol. Weight of Antigen
~67kDa

Functions

  • May act as a receptor in regulating T-cell proliferation.

Key References

  • Berezowski K; et al. American Journal of Clinical Pathology, 1996 Oct, 106(4):483-6.
  • Ferry JA; et al. American Journal of Clinical Pathology, 1996 Jan, 105(1):31-7.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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