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Recombinant CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody [rLPFS2/1611]

In Stock
Catalog Number Formulation Size Price
939-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
939-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
939-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human Tonsil stained with CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611).

Formalin-fixed, paraffin-embedded human Tonsil stained with CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611).

SDS-PAGE Analysis of Purified CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611). Confirmation of Integrity and Purity of Antibody.

Flow Cytometric Analysis of Ramos cells using CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Flow Cytometric Analysis of Ramos cells using CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFkB and SAPK/JNK and induces apoptosis.

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology, AKT Signaling, B Cell Markers, Cytokine Signaling
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane
Gene Name
CD27
Positive Control
Ramos cells. Human peripheral blood lymphocytes. Human tonsil and lymph node.
Immunogen
Recombinant human CD22 protein (exact sequence is proprietary)
Alternate Names
CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, LPFS2; S152; T cell activation antigen S152; T-cell activation antigen CD27; T14; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7

Database Links

Entrez Gene ID
939
SwissProt
P26842

Additional Information

Clone
rLPFS2/1611
Chromosome Location
12p13
Mol. Weight of Antigen
120kDa

Related Antibodies

View All CD27 Antibodies

Functions

  • Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

Key References

  • De Rie MA, Cairo I, Van Lier RA, Bos JD. Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin. Clin Exp Dermatol. 1996 Mar;21(2):104-11.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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