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CLEC9A Antibody [1F6]

In Stock
Catalog Number Formulation Size Price
MS232414-RTM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MS232414-RTM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MS232414-RTM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
CLEC9A Antibody in SDS-PAGE.

CLEC9A Antibody in SDS-PAGE.

SDS-PAGE Analysis Purified CLEC9A Rat anti-Mouse Monoclonal Antibody (1F6). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

This Mab recognizes mouse DNGR-1, which is also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognize a preformed signal exposed on necrotic cells. In peripheral blood, it is highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

Product Properties & Targets

Antibody Type
Rat Monoclonals
Host
Rat
Applications
Flow Cytometry, Immunofluorescence, Western Blot
Species Reactivity
Mouse
Isotype / Light Chain
IgG1 /
Cellular Localization
Membrane
Gene Name
CLEC9A
Positive Control
Mouse spleen.
Immunogen
RBL-2H3 cells expressing Mouse CLEC9A fused to an HA epitope.
Alternate Names
C-type lectin domain family 9 member A, Dendritic cell natural killer lectin group receptor 1, C type lectin domain family 9, member A; C-type lectin domain family 8 member A; CLEC9A; DNGR1; HEEE9341; PRO34046; UNQ9341; CD370

Database Links

Entrez Gene ID
232414 (Mouse)
SwissProt
Q8BRU4 (Mouse)

Additional Information

Clone
1F6
Chromosome Location
6,63.30 (Mouse)
Mol. Weight of Antigen
27kDa

Related Antibodies

View All CLEC9A Antibodies

Functions

  • Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Key References

  • Sancho et al. 2008. J Clin Invest 118:2098-110.
  • Sancho et al. 2009. Nature. 458:899-903.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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