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IPO-38 (Proliferation Marker) Antibody [IPO-38]

In Stock
Catalog Number Formulation Size Price
MSM1-697-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MSM1-697-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MSM1-697-P1BX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
IPO-38 (Proliferation Marker) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with IPO38 Monoclonal Antibody.

IPO-38 (Proliferation Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Tonsil stained with IPO38 Monoclonal Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 14-16kDa, which is a novel nuclear antigen of proliferating cells. IPO-38 antigen is present in the nuclei of proliferating cells such as Hodgkin's disease and non-Hodgkin's lymphomas, different forms of leukemias, breast and colorectal carcinomas, and PHA-stimulated lymphocytes. It is not expressed in the cells of non-stimulated lymphocytes and granulocytes. IPO-38 may be a useful marker of cell proliferation during monitoring of tumor progression.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human, Mouse, Rat
Isotype / Light Chain
IgM / Kappa
Cellular Localization
N/A
Gene Name
N/A
Positive Control
Raji and PHA-stimulated (>12 hours) human or mouse lymphocytes. Breast and colorectal carcinomas.
Immunogen
Spleen cells of a patient with hairy cell leukemia
Alternate Names
N/A, N/A, Not Known

Database Links

Entrez Gene ID
Not Known
SwissProt
N/A

Additional Information

Clone
IPO-38
Mol. Weight of Antigen
14-16kDa

Related Antibodies

View All N/A Antibodies

Functions

  • N/A

Key References

  • Sidorenko SP et al. Monoclonal antibodies of the IPO series in studying and diagnosing malignant lympho-proliferative diseases. Gematol Transfuziol 1990, 35(4):19-22.
  • Mikhalap SV et al. Monoclonal antibody IPO-38 recognizes a novel nuclear antigen of proliferating cells. In Kishimoto T et al eds. Leukocyte Typing VI, p609-610, Garland Publishing, New York, 1997.
  • Mathews MB et al. Identity of the proliferating cell nuclear antigen and cyclin. Nature 1984, 309:374-376.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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