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Recombinant Uroplakin 3B (UPK3B) (Marker of Mesothelial & Umbrella Cells) Antibody [UPK3B/8550R]

In Stock
Catalog Number Formulation Size Price
105375355-RBM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
105375355-RBM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
105375355-RBM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Uroplakin 3B (UPK3B) (Marker of Mesothelial & Umbrella Cells) Antibody

Formalin-fixed, paraffin-embedded human bladder stained with Uroplakin 3B Recombinant Rabbit Monoclonal Antibody (UPK3B/8550R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant Uroplakin 3B (UPK3B) (Marker of Mesothelial & Umbrella Cells) Antibody - Image 2

Formalin-fixed, paraffin-embedded human bladder stained with Uroplakin 3B Recombinant Rabbit Monoclonal Antibody (UPK3B/8550R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. �

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
ELISA, Immunohistochemistry
Species Reactivity
Human
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell surface. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum.
Gene Name
UPK3B
Positive Control
Human urinary bladder.
Immunogen
Recombinant fragment (around aa 100-300) of human Uroplakin 3B (UPK3B) protein (exact sequence is proprietary)
Alternate Names
Uroplakin-3b, Uroplakin IIIb, p35, FLJ32198; MGC10902; p35; UP3b; UPIIIb; UPK3B; UPK3B_HUMAN; uroplakin 3B; Uroplakin IIIb; Uroplakin-3b

Database Links

Entrez Gene ID
105375355
SwissProt
Q9BT76

Additional Information

Clone
UPK3B/8550R
Chromosome Location
19q13.12
Mol. Weight of Antigen
32kDa

Related Antibodies

View All UPK3B Antibodies

Functions

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).

Key References

  • Kristoffersen HL, et al. Comparison of Antibodies to Detect Uroplakin in Urothelial Carcinomas. Appl Immunohistochem Mol Morphol. 2022 May-Jun 01;30(5):326-332. doi: 10.1097/PAI.0000000000001021.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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