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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with ZNF690 / ZSCAN29 Mouse Monoclonal Antibody (PCRP-ZNF846-1E12). Inset: PBS instead of primary antibody; secondary only negative control.
Formalin-fixed, paraffin-embedded human colon carcinoma stained with ZNF690 / ZSCAN29 Mouse Monoclonal Antibody (PCRP-ZNF846-1E12). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using ZNF690 / ZSCAN29 Mouse Monoclonal Antibody (PCRP-ZNF846-1E12) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using ZNF846 Mouse Monoclonal Antibody (PCRP-ZNF846-1E12) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF846 may be involved in transcriptional regulation.
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