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S100A2 / S100 Calcium Binding Protein A2 Antibody [S100A2/6925]

In Stock
Catalog Number Formulation Size Price
6273-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6273-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6273-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
S100A2 / S100 Calcium Binding Protein A2 Antibody

Formalin-fixed, paraffin-embedded human cervix stained with S100A2 Mouse Monoclonal Antibody (S100A2/6925). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

S100A2 / S100 Calcium Binding Protein A2 Antibody - Image 2

Formalin-fixed, paraffin-embedded human placenta stained with S100A2 Mouse Monoclonal Antibody (S100A2/6925). Inset: PBS instead of primary antibody; secondary only negative control.

S100A2 / S100 Calcium Binding Protein A2 Antibody - Image 3

SDS-PAGE Analysis of Purified S100A2 Mouse Monoclonal Antibody (S100A2/6925). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

S100A2 belongs to the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100A2 may function as a modulator against excess calcium accumulation in normal human mammary epithelial cells and also have a role in suppressing tumor cell growth. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. Cytoplasmic overexpression may also be of prognostic significance when observed in oral cancer patients, and the S100A2 has also been identified as significantly down regulated in gastric cancer.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Nucleus. Cytoplasm.
Gene Name
S100A2
Positive Control
and A431 cell lysates; Skin and squamous cell cervical carcinoma.|BxPC3|HACAT|HeLa. A549
Immunogen
Recombinant full-length human S100A2 protein
Alternate Names
Protein S100-A2, CAN19, Protein S-100L, S100 calcium-binding protein A2, CAN19; MGC111539; S100L

Database Links

Entrez Gene ID
6273
SwissProt
P29034

Additional Information

Clone
S100A2/6925
Chromosome Location
1q21.3
Mol. Weight of Antigen
11.12kDa

Related Antibodies

View All S100A2 Antibodies

Functions

  • May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.

Key References

  • Wessels D, et al. PLoS ONE 12(3): e0173400.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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