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Recombinant CXCR5 / CXCL13 / CD185 Antibody [CXCR5/8146R]

In Stock
Catalog Number Formulation Size Price
643-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
643-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
643-RBM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human tonsil stained with CXCR5 Recombinant Rabbit Monoclonal Antibody (CXCR5/8146R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human tonsil stained with CXCR5 Recombinant Rabbit Monoclonal Antibody (CXCR5/8146R). Inset: PBS instead of primary antibody; secondary only negative control.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Burkitt s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B-lymphocyte chemoattractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B-cell migration into splenic and Peyer s patch follicles. BLC expression in Peyer s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, AKT Signaling, B Cell Markers, Signal Transduction
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell membrane
Gene Name
CXCR5
Positive Control
Human tonsil or diffuse large b-lymphoma.
Immunogen
Recombinant fragment (around aa1-200) of human CXCR5 protein (exact sequence is proprietary)
Alternate Names
C-X-C chemokine receptor type 5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, BLR1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5); CD185 antigen; Chemokine receptor 5; CXC chemokine receptor type 5; MDR 15; MDR15; MGC117347; Monocyte derived receptor 15

Database Links

Entrez Gene ID
643
SwissProt
P32302Human

Additional Information

Clone
CXCR5/8146R
Chromosome Location
11q23.3
Mol. Weight of Antigen
56kDa

Related Antibodies

View All CXCR5 Antibodies

Functions

  • Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Key References

  • Zhao, J., et al. 2022. Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome. Biochem. Pharmacol. 200: 115047.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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