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11 January, 2024 by Anshul (neobio)
Welcome to our comprehensive guide on understanding CD11c Marker on macrophages. We aim to explain the complexities of this marker in a simple, digestible manner for both seasoned experts and individuals who are new to the field of immunology.
In the realm of immunology, the CD11c marker is considered a cornerstone of our understanding of dendritic cells and macrophages. Pivotal to the body’s immune system, macrophages play a critical role in identifying, engulfing, and eliminating pathogens. The CD11c marker, which finds robust expression in dendritic cells and certain macrophages, is an integral part of this process.
At NeoBiotechnologies, we specialize in supplying highly validated, monospecific antibodies, such as those to detect the CD11c marker. This crucial tool aids researchers on the frontline of advancing our understanding of the immune system and combating disease.
Let’s quickly glance at some takeaways to better understand the CD11c marker:
– Master Player: CD11c is more than a definitive marker for dendritic cells – it’s found in an array of immune cells, including certain macrophages.
– Key Functions: CD11c, part of the complement receptor 4 (CR4) and the β2 integrin family of adhesion molecules, is crucial for cellular adherence, migration and phagocytosis.
– Beyond Basic Immunology: CD11c has a vital role in the regulation of hematopoietic stem and progenitor cells (HSPs) under stress, and research continues into more unexplored functions.
– A Diagnostic Marker: In oncology, CD11c helps in diagnosing cancers like hairy cell leukemia, acute myeloid leukemia and some chronic lymphocytic leukemias.
This guide aims to untangle the role and significance of the CD11c marker on macrophages, illustrating its fundamental importance in the immune system and why it deserves the attention it garners from the scientific community. Let’s embark on this journey together!
The CD11c marker is a protein found on the surface of certain immune cells, including macrophages, a type of white blood cell that engulfs and digests cellular debris and foreign substances. Our research shows that the presence of CD11c marker is significant in the identification of macrophage subsets like CD11c+ M1-like macrophages.
It is important to understand that not all macrophages express CD11c. The expression of this marker can vary depending on several factors, including the stage of cell development and the specific subset of the macrophage.
Macrophages are generally classified into two major subsets: M1 and M2. However, the expression of CD11c is not exclusive to one type. In a study published in Nature, it was discovered that CD11c+ M1-like macrophages, but not CD206+ M2-like macrophages, are involved in folliculogenesis in mice ovary. This highlights the unique roles of different macrophage subsets and the correlation with the CD11c marker.
Folliculogenesis, the maturation of the ovarian follicle, and ovulation are complex processes that require the involvement of various immune cells, including macrophages. CD11c+ M1-like macrophages have been found to play a crucial role in folliculogenesis. Research reveals that the proportion of CD11c+ M1-like macrophages increases during follicular induction, suggesting their involvement in this process.
The depletion of CD11c+ macrophages can have a significant impact on folliculogenesis. In studies conducted on CD11c DTR mice, which enable the selective depletion of CD11c+ macrophages, it was observed that folliculogenesis was impaired when CD11c+ macrophages were depleted. This further emphasizes the critical role of CD11c+ macrophages in reproductive biology.
At NeoBiotechnologies, we understand the importance of these findings and their implications in health and disease. Our selection of highly validated, monospecific Rabbit Recombinant Monoclonal Antibodies can be effectively used in investigating the role of CD11c+ macrophages in various biological processes.
In conclusion, the CD11c marker serves as a powerful tool in distinguishing macrophage subsets and understanding their unique roles in the immune system and reproductive biology. As we continue to uncover the mysteries of the immune system, the CD11c marker in macrophages will undoubtedly remain a critical area of focus in immunology research.
As we delve further into the role of the CD11c marker in disease conditions and research, it becomes evident that our understanding of this marker extends beyond the immune system and reproductive biology. It has significant implications in neuroinflammation, cancer research, and the development of humanized mouse models for research.
Neuroinflammation is a critical factor in a number of neurological conditions, including autoimmune diseases such as multiple sclerosis. Research has shown that the CD11c marker is expressed by activated microglia, the resident immune cells of the brain, during disease conditions (Benmamar-Badel et al., 2020). This expression of CD11c by activated microglia suggests a potential role for CD11c+ cells in neuroinflammation and provides a potential target for therapeutic intervention.
In the field of oncology, the CD11c marker has emerged as a significant diagnostic tool. It’s an important marker for the diagnosis of certain types of leukemia such as hairy cell leukemia (Maitre et al., 2019), acute myeloid leukemia (Master et al., 1989), and some chronic lymphocytic leukemias (Umit et al., 2017). Detecting and quantifying the expression of the CD11c marker can provide valuable insights into the disease status and progression, and guide therapeutic decisions.
At NeoBiotechnologies, we understand the importance of accurate and reliable research tools. In this context, the CD11c marker has proven to be particularly useful in the development of humanized mouse models. These are mice that have been engineered to have human cells or tissues, and they are vital tools in studying human diseases and testing potential treatments.
The HistoSure CD11c antibodies offered by us are mouse-specific and do not cross-react with human CD11c. This means they can distinguish murine from human cells in humanized mouse models (HistoSure). This specificity is crucial in accurately monitoring the interactions between human and mouse cells, and in understanding the human immune response in vivo.
In conclusion, the CD11c marker macrophage is not just a marker for dendritic cells and macrophages, but also a valuable tool in disease research and therapeutics. As we continue to make strides in understanding the complex interactions within the immune system, the role of CD11c will undoubtedly continue to be a focus of scientific inquiry.
To summarize, the CD11c marker plays a critical role in the functioning of the immune system. It is expressed in a variety of immune cells, including macrophages and dendritic cells. The presence of CD11c can help distinguish between different subsets of these immune cells, offering valuable insight into the complex interactions within the immune system.
The CD11c marker macrophage is not just a tool for scientific inquiry, but also has significant potential applications in biomedical research. For instance, it can be utilized in cancer research and diagnosis due to its expression in certain leukemia cells. Furthermore, the marker is instrumental in the study of neuroinflammation and other disease conditions.
At NeoBiotechnologies, we understand the importance of reliable and highly validated antibodies for your research. That’s why we manufacture a range of monospecific Rabbit Recombinant Monoclonal Antibodies, ideal for applications such as Immunohistochemistry, Flow Cytometry, Western Blotting, and Immunofluorescence.
Looking ahead, further exploration of the CD11c marker could provide crucial understanding of the immune system and its role in various diseases. For instance, the impact of CD11c expression on macrophage function and behavior in different conditions is a potential area of study.
Moreover, as research technologies evolve, there are opportunities to develop more precise and accurate detection methods for the CD11c marker. This would allow for more nuanced understanding of its role within the immune system, and potentially pave the way for novel therapeutic strategies.
In conclusion, the CD11c marker is a powerful tool in the study of the immune system. It offers valuable insights into the functions of macrophages and other immune cells, and has considerable potential for future research and therapeutic applications. At NeoBiotechnologies, we are dedicated to supporting your research efforts and look forward to the exciting discoveries that lie ahead in the field of CD11c marker research.