APC Antibodies

Adenomatous Polyposis Coli (APC) is involved in the Wnt signaling pathway. With a molecular weight of approximately 310 kDa, APC is primarily expressed intracellularly, functioning as a critical regulator of cellular processes. This multifunctional protein undergoes posttranslational modifications, including phosphorylation and ubiquitination, which tightly regulate its stability and activity.

The key role of APC lies in the negative regulation of the Wnt signaling pathway. APC acts as a tumor suppressor by forming a complex with Axin and GSK-3β, leading to the degradation of β-catenin. In the absence of Wnt signaling, this degradation prevents the accumulation of β-catenin, thereby suppressing cell proliferation and promoting apoptosis.

APC is ubiquitously expressed in various cells and tissues, with particularly significant roles in the gastrointestinal tract. In the colon, its expression is crucial for maintaining epithelial homeostasis and preventing the formation of polyps and tumors. The expression of APC is modulated during the cell cycle, and mutations in the APC gene are associated with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. Understanding APC’s role in colorectal cancer has opened avenues for targeted therapeutic interventions aimed at restoring normal Wnt signaling.

Antibodies against APC have diverse applications in research and diagnostics. In the clinical setting, these antibodies are used for immunohistochemistry (IHC) to assess APC expression levels in tissue samples. Such evaluations contribute to diagnostic assessments, prognostic predictions, and determining treatment strategies in colorectal cancer. The availability of reliable APC antibodies is essential for researchers and clinicians seeking to unravel the intricacies of APC’s involvement in cancer and explore potential therapeutic avenues.

At Neobiotechnologies, we offer a comprehensive range of high-quality antibodies, including those targeting APC, to support researchers and clinicians in their quest for scientific discoveries and improved patient outcomes. Explore our catalog to access cutting-edge tools that contribute to advancing knowledge and applications in cancer research and diagnostics.

Synonyms

Adenomatous polyposis coli protein, Deleted in polyposis 2.5, Adenomatous Polyposis Coli; CC1; Deleted in polyposis 2.5 (DP2.5); DP2; DP3; FAP; FPC; GS; Protein APC

Research Areas

Breast Cancer, Cardiovascular, Colon Cancer, Infectious Disease, Ovarian Cancer, Signal Transduction