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CD79A Antibodies

CD79a, also known as immunoglobulin-associated alpha (Ig-α), is a protein encoded by the CD79A gene on chromosome 19q13.2. It contains approximately 226 amino acids and has a molecular weight of around 27 kDa. CD79a is primarily a membrane protein, forming a heterodimer with CD79b to constitute the B cell antigen receptor (BCR) complex. The BCR complex is essential for B cell development, activation, and signaling, serving as a key component of the adaptive immune response. CD79a undergoes post-translational modifications such as phosphorylation, which regulate its function and downstream signaling pathways.

The main function of CD79a is to transduce signals from the BCR to the intracellular signaling machinery upon antigen recognition. Upon binding to antigen, the BCR complex, consisting of CD79a/CD79b and membrane-bound immunoglobulin (Ig) molecules, undergoes conformational changes and initiates signaling cascades that lead to B cell activation, proliferation, and differentiation. CD79a plays a critical role in B cell receptor-mediated signaling and antigen presentation, thereby coordinating the adaptive immune response to pathogens and foreign antigens.

CD79a is predominantly expressed in B lymphocytes throughout various stages of B cell development, from early progenitors in the bone marrow to mature B cells in peripheral lymphoid organs. Its expression is tightly regulated during B cell differentiation and activation, with dynamic changes observed in response to antigen binding, cytokine stimulation, and cellular differentiation signals. Dysregulation of CD79a expression or function can disrupt B cell receptor signaling and impair immune responses, contributing to immunodeficiency disorders, autoimmune diseases, and B cell malignancies.

CD79a is a biomarker with diagnostic and prognostic value, particularly in B-cell lymphomas and leukemias. As a component of the BCR complex, CD79a is expressed throughout B-cell development and commonly utilized as an immunohistochemical marker to confirm the B-cell lineage of tumor cells in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. Its expression aids in distinguishing B-cell lymphomas from other lymphoid malignancies, with abnormal expression patterns indicating B-cell neoplasms. Additionally, CD79a expression levels and patterns may hold prognostic significance, particularly in DLBCL, where intensity and extent of expression may correlate with clinical outcomes and treatment response. Notably, loss or reduced expression of CD79a in B-cell lymphomas may signify a more aggressive disease phenotype and poorer prognosis.

NeoBiotechnologies offers a variety of antibodies against CD79a that have been validated for ELISA, flow cytometry, immunofluorescence, immunohistochemistry, and Western blotting. Additionally, we hold exclusive rights to CD79a antibodies available for licensing or collaboration [https://www.neobiotechnologies.com/gene-name/cd79a/].

Synonyms

B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, B lymphocyte-specific MB1 protein, B-cell antigen receptor complex-associated protein alpha chain, CD79a molecule immunoglobulin associated alpha, Ig-alpha, IGA, IgM-alpha, Immunoglobulin-associated alpha, Ly54, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein

Research Areas

Immunology, B Cell Markers, Hematopoietic Stem Cells, Infectious Disease, Mesenchymal Stem Cell Differentiation

Showing all 16 results

CD79A

Showing all 16 results

  • In Stock

    CD79a (B Cell Marker) Antibody [JCB117 + HM47/A9]

    $229.00$519.00
    Catalog Number:
    973-MSM3
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Cow, Human, Monkey, Mouse, Pig, Rat
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B Cell Marker) Antibody [IGA/764]

    $229.00$519.00
    Catalog Number:
    973-MSM4
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [JCB117]

    $229.00$519.00
    Catalog Number:
    973-MSM1
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [ZL7-4]

    $229.00$519.00
    Catalog Number:
    973-MSM12
    Gene:
    CD79A
    Application:
    ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [SPM549]

    $229.00$519.00
    Catalog Number:
    973-MSM1X
    Gene:
    CD79A
    Application:
    Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [HM47/A9]

    $229.00$519.00
    Catalog Number:
    973-MSM2
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Cow, Human, Monkey, Mouse, Pig, Rat
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [SPM550]

    $229.00$519.00
    Catalog Number:
    973-MSM2X
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry
    Reactivity:
    Cow, Human, Monkey, Mouse, Pig, Rat
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [IGA/515]

    $229.00$519.00
    Catalog Number:
    973-MSM5
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [IGA/1406]

    $229.00$519.00
    Catalog Number:
    973-MSM6
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG3
  • In Stock

    CD79a (B-Cell Marker) Antibody [HM57]

    $229.00$519.00
    Catalog Number:
    973-MSM7
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Cow, Human, Monkey, Mouse, Pig, Rat
    Host:
    Mouse
    Isotype:
    IgG1
  • In Stock

    CD79a (B-Cell Marker) Antibody [N/A]

    $229.00$519.00
    Catalog Number:
    973-RBP9
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry
    Reactivity:
    Human, Mouse, Rat
    Host:
    Rabbit
    Isotype:
    IgG
  • Recombinant
    In Stock

    Recombinant CD79a (B-Cell Marker) Antibody [rIGA/764]

    $229.00$519.00
    Catalog Number:
    973-MSM11
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
  • Recombinant
    In Stock

    Recombinant CD79a (B-Cell Marker) Antibody [IGA/1790R]

    $229.00$519.00
    Catalog Number:
    973-RBM10
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Cow, Dog, Human, Monkey, Mouse, Pig, Rat
    Host:
    Rabbit
    Isotype:
    IgG
  • Recombinant
    In Stock

    Recombinant CD79a (B-Cell Marker) Antibody [IGA/3939R]

    $229.00$519.00
    Catalog Number:
    973-RBM13
    Gene:
    CD79A
    Application:
    Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Rabbit
    Isotype:
    IgG
  • Recombinant
    In Stock

    Recombinant CD79a (B-Cell Marker) Antibody [IGA/1688R]

    $229.00$519.00
    Catalog Number:
    973-RBM8
    Gene:
    CD79A
    Application:
    Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
    Reactivity:
    Human, Mouse, Rat
    Host:
    Rabbit
    Isotype:
    IgG
  • Recombinant
    In Stock

    Recombinant CD79a (B-Cell Marker) Antibody [rIGA/6986]

    $229.00$519.00
    Catalog Number:
    973-MSM16
    Gene:
    CD79A
    Application:
    Immunohistochemistry, Western Blot
    Reactivity:
    Human
    Host:
    Mouse
    Isotype:
    IgG1
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