HBsAg Antibodies

Hepatitis B Surface Antigen (HBsAg) has a molecular weight of approximately 24 kDa. This viral protein is expressed on the surface of the hepatitis B virus (HBV) particles and is also produced and secreted by infected hepatocytes. It is involved in forming the outer envelope of the HBV virion, playing a critical role in the attachment of the virus to host cells during the infection process.

HBsAg is associated with hepatitis B, a viral infection that can lead to acute or chronic liver disease. Additionally, chronic hepatitis B infection is a significant risk factor for the development of cirrhosis and liver cancer (hepatocellular carcinoma).

Antibodies against HBsAg are used in diagnostic tests to detect the presence of the antigen in serum or plasma. These antibodies can be part of assays such as enzyme-linked immunosorbent assay (ELISA) for hepatitis B screening.

Clinically, the detection of HBsAg is a primary marker for diagnosing current hepatitis B infection. In fact, serological testing for HBsAg is an essential component of routine screening for hepatitis B. Therapeutically, vaccination against Hepatitis B Surface Antigen is a widely used preventive measure against hepatitis B infection.

Synonyms

Large envelope protein, L glycoprotein, L-HBsAg, Large S protein, Large surface protein, Major surface antigen, HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S antibody

Research Areas

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