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Mouse Double Minute 2 (MDM2) has a molecular weight of approximately 90 kDa. This protein is expressed in various tissues, with higher levels often found in proliferating cells. It has several functions, with its most well-known role in inhibiting p53 transcriptional activity, leading to the degradation of p53 and preventing its function as a tumor suppressor. It also has p53-independent functions, including its involvement in cell cycle regulation and apoptosis.
MDM2 is often overexpressed in various cancers, leading to the inactivation of p53 and contributing to tumorigenesis by allowing cells with damaged DNA to avoid apoptosis and continue to divide. Notably, some cancers exhibit amplification or overexpression of the Mouse Double Minute 2 gene.
Antibodies against MDM2 are used in research to study its expression levels in cells and tissues. Immunohistochemistry and western blotting techniques employing anti-MDM2 antibodies help researchers analyze its role in cancer and other diseases.
E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, ACTFS; Double minute 2 protein; E3 ubiquitin-protein ligase; Hdm2; HDMX; MDM2; MDM2 oncogene E3 ubiquitin protein ligase; MDM2BP; Mouse Double Minute 2; MTBP; Murine Double Minute Chromosome 2; p53 Binding Protein Mdm2; p53-binding protein Mdm2
Cardiovascular, AKT Signaling, Bladder Cancer, Infectious Disease, Nuclear Marker, Signal Transduction, Transcription Factors
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