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ADCY8 (Adenylate Cyclase 8) Antibody [ADCY8/7341]

In Stock
Catalog Number Formulation Size Price
114-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
114-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
114-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human brain stained with ADCY8 Mouse Monoclonal Antibody (ADCY8/7341). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human brain stained with ADCY8 Mouse Monoclonal Antibody (ADCY8/7341). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human kidney stained with ADCY8 Mouse Monoclonal Antibody (ADCY8/7341). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human kidney stained with ADCY8 Mouse Monoclonal Antibody (ADCY8/7341). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

SDS-PAGE Analysis of Purified ADCY8 Mouse Monoclonal Antibody (ADCY8/7341). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified ADCY8 Mouse Monoclonal Antibody (ADCY8/7341). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Colon Cancer, Infectious Disease, Neuroinflammation, Signal Transduction
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell surface. Multi-pass membrane protein. Cytoplasm.
Gene Name
ADCY8
Positive Control
Human brain tissue.
Immunogen
Recombinant fragment (around aa1-200) of human ADCY8 protein (exact sequence is proprietary)
Alternate Names
Adenylate cyclase type 8, ATP pyrophosphate-lyase 8, Adenylate cyclase type VIII, Adenylyl cyclase 8, Ca(2+)/calmodulin-activated adenylyl cyclase, ADCY3; Adenylate cyclase type VIII; ATP pyrophosphate-lyase 8; Brain adenylate cyclase 8; Ca(2+)/calmodulin activated adenylyl cyclase; EC 4.6.1.1; HBAC1

Database Links

Entrez Gene ID
114
SwissProt
P40145Human

Additional Information

Clone
ADCY8/7341
Chromosome Location
8q24.22
Mol. Weight of Antigen
140kDa

Related Antibodies

View All ADCY8 Antibodies

Functions

  • Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells.

Key References

  • Zheng Q, et al Biosci Rep. 2021 Jun 25;41(6):BSR20204370. doi: 10.1042/BSR20204370.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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