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Recombinant Androgen Receptor (Marker of Androgen Dependence) Antibody [DHTR/4929R]

In Stock
Catalog Number Formulation Size Price
367-RBM9-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
367-RBM9-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
367-RBM9-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified AR Recombinant Rabbit Monoclonal Antibody (DHTR/4929R). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified AR Recombinant Rabbit Monoclonal Antibody (DHTR/4929R). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Recombinant Rabbit Monoclonal Antibody (DHTR/4929R). HIER: Tris/EDTA, pH9.0, 95°C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Recombinant Rabbit Monoclonal Antibody (DHTR/4929R). HIER: Tris/EDTA, pH9.0, 95°C/45min. 2°CAb: HRP-Poly:30min. DAB:5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Androgen Receptor is a member of the superfamily of ligand responsive transcription regulators. The androgen receptor functions in the nucleus where it is believed to act as a transcriptional regulator mediating the action of male sex hormones. The androgen receptor has wide distribution and can be demonstrated by immunohistochemistry in several tissues including prostate, skin, and oral mucosa. Androgen receptor has been reported in a diverse range of human tumors including osteosarcoma, and in prostatic carcinoma androgen receptor expression may be of clinical relevance.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
AKT Signaling, Signal Transduction, Transcription Factors
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus.
Gene Name
AR
Positive Control
Breast|LNCap cells. Human testis|prostate or prostate carcinoma.
Immunogen
Recombinant human AR protein (exact sequence is proprietary)
Alternate Names
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AIS; Dihydrotestosterone receptor (DHTR); HUMARA; HYSP1; Kennedy disease (KD); Nuclear receptor subfamily 3 group C member 4 (NR3C4); SMAX1; Spinal and bulbar muscular atrophy (SBMA); Testicular Feminization (TFM)

Database Links

Entrez Gene ID
367
SwissProt
P10275Human

Additional Information

Clone
DHTR/4929R
Chromosome Location
Xq12
Mol. Weight of Antigen
110kDa

Related Antibodies

View All AR Antibodies

Functions

  • Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
  • Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
  • Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.

Key References

  • Janne OA, et al. Androgen receptor and mechanism of androgen action. Ann Med 1993; 25:83
  • Siu MK, et al. Oncogenesis 5:e282 (2016).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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