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B7-H6 / NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) Antibody [B7H6/4821]

In Stock
Catalog Number Formulation Size Price
374383-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
374383-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
374383-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
B7-H6 / NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) Antibody

Formalin-fixed, paraffin-embedded human liver carcinoma in colon stained with B7-H6 / NCR3LG1 Mouse Monoclonal Antibody (B7H6/4821).

B7-H6 / NCR3LG1 (Natural Killer Cell Cytotoxicity Receptor 3 Ligand 1) Antibody - Image 2

Formalin-fixed, paraffin-embedded human tonsil stained with B7-H6 / NCR3LG1 Mouse Monoclonal Antibody (B7H6/4821).

B7-H6 Antibody in SDS-PAGE

B7-H6 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified B7-H6 Mouse Monoclonal Antibody (B7H6/4821). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
NCR3LG1
Positive Control
HeLa or K562 cells. Human tonsil or gallbladder.
Immunogen
Recombinant fragment (around aa38-169) of human NCR3LG protein (exact sequence is proprietary)
Alternate Names
Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, Natural cytotoxicity triggering receptor 3 ligand 1 (NCTR3L1); B7 Homolog 6 (B7H6)

Database Links

Entrez Gene ID
374383
SwissProt
Q68D85

Additional Information

Clone
B7H6/4821
Chromosome Location
11p15.1
Mol. Weight of Antigen
51kDa

Related Antibodies

View All NCR3LG1 Antibodies

Functions

  • Triggers NCR3-dependent natural killer cell activation.

Key References

  • Zhang, B, et al. Oncol Lett. 2019 Jul; 16(1): 91-96.
  • Brandt CS, et al. J Exp Med. 2009;206:1495 1503.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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