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SDS-PAGE Analysis of Purified BCL2L2 Mouse Monoclonal Antibody (PCRP-BCL2L2-1A4). Confirmation of Purity and Integrity of Antibody.
Flow cytometric analysis of PFA-fixed Raji cells. BCL2L2 Mouse Monoclonal Antibody (PCRP-BCL2L2-1A4) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
Immunofluorescence Analysis of PFA-fixed MCF-7 cells stained using BCL2L2 Mouse Monoclonal Antibody (PCRP-BCL2L2-1A4) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red).
Immunofluorescence Analysis of PFA-fixed U87 cells stained using BCL2L2 Mouse Monoclonal Antibody (PCRP-BCL2L2-1A4) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using BCL2-like 2 Mouse Monoclonal Antibody (PCRP-BCL2L2-1A4). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
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