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Formalin-fixed, paraffin-embedded human smooth muscle stained with h-CALD Recombinant Mouse Monoclonal Antibody (rCALD1/7266). Inset: PBS instead of primary antibody; secondary only negative control.
Formalin-fixed, paraffin-embedded human smooth muscle stained with h-CALD Recombinant Mouse Monoclonal Antibody (rCALD1/7266). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis of Purified Caldesmon, HMW Recombinant Mouse Monoclonal Antibody (rCALD1/7266). Confirmation of Purity and Integrity of Antibody.
Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120 150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70 80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.
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