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Western blot analysis: HT20, 293, A431, MCF-7, HepG2 & A549 cell lysates using Catenin, gamma Mouse Monoclonal Antibody (15F11).
Immunofluorescence Analysis of PFA-fixed HeLa cells stained using Catenin, gamma Mouse Monoclonal Antibody (15F11) followed by goat anti-mouse IgG-CF488 (green). Nuclei stained with RedDot (red).
Western blot analysis of HeLa and SK-BR3 cell lysates using Catenin, gamma Mouse Monoclonal Antibody (15F11).
Flow Cytometric Analysis of PFA-fixed MCF-7 cells. Catenin, gamma Mouse Monoclonal Antibody (15F11) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
Formalin-fixed, paraffin-embedded human cervix stained with Catenin, gamma Mouse Monoclonal Antibody (15F11). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.
It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (伪, 尾, 纬 and �L) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. 伪 T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. 伪 T-catenin binds to 伪 E-catenin as well as to 尾-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for 伪-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
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