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CD11c (Dendritic Cell Marker) Antibody [HC1/1]

In Stock
Catalog Number Formulation Size Price
3687-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3687-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3687-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
FCM staining of human PBMCs using CD11c Monoclonal Antibody (HC1/1).

FCM staining of human PBMCs using CD11c Monoclonal Antibody (HC1/1).

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute non-lymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Human
Research Areas
Immunology, AKT Signaling, Complement System, Cytokine Signaling, Dendritic Cell Marker, Hematopoietic Stem Cells
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane
Gene Name
ITGAX
Positive Control
Human dendritic cells. Human lymph nodes and tonsils.
Immunogen
Human monocytic U937 phorbol ester-treated cells
Alternate Names
Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95

Database Links

Entrez Gene ID
3687
SwissProt
P20702

Additional Information

Clone
HC1/1
Chromosome Location
16p11.2
Mol. Weight of Antigen
145kDa

Related Antibodies

View All ITGAX Antibodies

Functions

  • Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Key References

  • Nicolaou, F., et al. 2003. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes Ras and JunD. Blood 101: 4033-4041.
  • Edwards, A.D., et al. 2003. Relationships among murine CD11c (high) dendritic cell subsets as revealed by baseline gene expression patterns. J. Immunol. 171: 47-60.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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