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CD2 / Lymphocyte Function Antigen 2 (LFA-2) Antibody [RPA-2.10]

In Stock
Catalog Number Formulation Size Price
914-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
914-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
914-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified CD2 Mouse Monoclonal Antibody (RPA-2.10). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified CD2 Mouse Monoclonal Antibody (RPA-2.10). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Baboon, Chimpanzee, Human, Monkey, Pig
Research Areas
AKT Signaling, B Cell Markers, Hematopoietic Stem Cells
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
CD2
Positive Control
293T or Jurkat cells. Lymph node and tonsil.
Immunogen
Recombinant full-length human CD2 protein
Alternate Names
T-cell surface antigen CD2, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5, Erythrocyte receptor; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; Rosette receptor; SRBC; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5; T11

Database Links

Entrez Gene ID
914
SwissProt
P06729

Additional Information

Clone
RPA-2.10
Chromosome Location
1p13.1
Mol. Weight of Antigen
~50kDa

Related Antibodies

View All CD2 Antibodies

Functions

  • CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Key References

  • Zaretsky AG, et al. 2009. J. Exp Med. 206:991. (IF)
  • Perona-Wright G, et al. 2010. Nat. Immunol. 11:520. (FC)

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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