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Formalin-fixed, paraffin-embedded human tonsil stained with CD20 Mouse Recombinant Monoclonal Antibody (rIGEL/773).
Formalin-fixed, paraffin-embedded human lymph node stained with CD20 Mouse Recombinant Monoclonal Antibody (rIGEL/773).
Flow Cytometric Analysis of Raji cells. CD20 Recombinant Mouse Monoclonal Antibody (rIGEL/773) followed bygoat anti-mouse IgG-CF488 (blue); isotype control (red).
SDS-PAGE Analysis PurifiedCD20 Mouse Recombinant Monoclonal Antibody (rIGEL/773). Confirmation of Purity and Integrity of Antibody.
Immunofluorescence staining of Raji cells using CD20 Mouse Recombinant Monoclonal Antibody (rIGEL/773) followed by goat anti-mouse IgG-CF488 (green). Nuclei stained with RedDot.
Analysis of Protein Array containing more than 19,000 full-length human proteins using CD20 Monospecific Recombinant Mouse Monoclonal Antibody (rIGEL/773). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Western Blot Analysis of Raji cell lysate using CD20 Recombinant Mouse Monoclonal Antibody (rIGEL/773).
Western Blot Analysis of Raji cell lysate using CD20 Mouse Monoclonal Antibody (rIGEL/773).
Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre-B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.
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