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Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody [rCR2/1952]

In Stock
Catalog Number Formulation Size Price
1380-MSM11-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1380-MSM11-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1380-MSM11-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human spleen stained with CD21 Recombinant Mouse Monoclonal Antibody (rCR2/1952).

Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human spleen stained with CD21 Recombinant Mouse Monoclonal Antibody (rCR2/1952).

Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody - Image 3

SDS-PAGE Analysis of Purified CD21 Recombinant Mouse Monoclonal Antibody (rCR2/1952). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 140kDa, which is identified as the complement receptor 2(CR2)/CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro.CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha.CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology, B Cell Markers, Complement System, Dendritic Cell Marker
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
CR2
Positive Control
WEHI-231 cells. Human tonsil (IHC).
Immunogen
Recombinant fragment (around aa 44-196) of human CR2 (CD21) protein (exact sequence is proprietary)
Alternate Names
Complement receptor type 2, Complement C3d receptor, Epstein-Barr virus receptor, CD21; Complement C3d receptor (C3DR); Complement Receptor type 2 (CR2); CVID7; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; SLEB9

Database Links

Entrez Gene ID
1380
SwissProt
P20023

Additional Information

Clone
rCR2/1952
Chromosome Location
1q32
Mol. Weight of Antigen
140kDa

Related Antibodies

View All CR2 Antibodies

Functions

  • Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047).
  • (Microbial infection) Acts as a receptor for Epstein-Barr virus.

Key References

  • Otsuka, M., et al. 2004. Role of CD21 antigen in diffuse large B-cell lymphoma and its clinical significance. Br. J. Haematol. 127: 416-4

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA &azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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