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Recombinant CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) Antibody [CR2/3990R]

In Stock
Catalog Number Formulation Size Price
1380-RBM12-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1380-RBM12-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1380-RBM12-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human tonsil stained with CD21 Recombinant Rabbit Monoclonal Antibody (CR2/3990R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human tonsil stained with CD21 Recombinant Rabbit Monoclonal Antibody (CR2/3990R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human tonsil stained with CD21 Recombinant Rabbit Monoclonal Antibody (CR2/3990R).

Formalin-fixed, paraffin-embedded human tonsil stained with CD21 Recombinant Rabbit Monoclonal Antibody (CR2/3990R).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

CD21 also known as complement C3d receptor, Epstein-Barr virus receptor, and complement receptor type 2 (CR2), is a protein that in humans is encoded by the CR2 gene. This protein is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation.It is expressed by follicular dendritic cells (FDC) and mature B cells, as well as by several types of epithelial cells. CD21 is useful in the identification of follicular dendritic cell matrix found in normal lymph node and tonsillar tissue, and also useful in identifying abnormal.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology, B Cell Markers, Complement System, Dendritic Cell Marker
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell membrane
Gene Name
CR2
Positive Control
Human tonsil tissue.
Immunogen
Synthetic peptide corresponding to CD21 residues within aa933-C terminal of CD21
Alternate Names
Complement receptor type 2, Complement C3d receptor, Epstein-Barr virus receptor, CD21; Complement C3d receptor (C3DR); Complement Receptor type 2 (CR2); CVID7; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; SLEB9

Database Links

Entrez Gene ID
1380
SwissProt
P20023

Additional Information

Clone
CR2/3990R
Chromosome Location
1q32
Mol. Weight of Antigen
140kDa

Related Antibodies

View All CR2 Antibodies

Functions

  • Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU (PubMed:7753047). Participates in B lymphocytes activation (PubMed:7753047).
  • (Microbial infection) Acts as a receptor for Epstein-Barr virus.

Key References

  • Barel M, et al. Mol Immunol. 1995 Apr;32(6):389-97.
  • Tanner J, et al. J Virol. 1988 Dec;62(12):4452-64.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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