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CD4 (T-Helper/Inducer Cell Marker) Antibody [CD4/1604]

In Stock
Catalog Number Formulation Size Price
920-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
920-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
920-MSM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified CD4 Mouse Monoclonal Antibody (CD4/1604). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified CD4 Mouse Monoclonal Antibody (CD4/1604). Confirmation of Integrity and Purity of Antibody.

Flow cytometry of lymphocyte gated PBMCs stained with CD4 mouse monoclonal antibody (CD4/1604) (red) or isotype control (gray) followed by goat anti-mouse CF640R.

Flow cytometry of lymphocyte gated PBMCs stained with CD4 mouse monoclonal antibody (CD4/1604) (red) or isotype control (gray) followed by goat anti-mouse CF640R.

Summary

Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. The majority of peripheral T-cell lymphomas are derived from the T-helper/regulatory cell subset so that most mature T-cell neoplasms are CD4+/CD8-. Anti-CD4 is used in the immunohistochemical staining of lymphoproliferative disorders to evaluate tumors with CD4 aberrant expression.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, AKT Signaling, Cytokine Signaling, Hematopoietic Stem Cells, Infectious Disease
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cell membrane
Gene Name
CD4
Positive Control
CCRF-CEM or HL-60. Lymph node or tonsil., Human peripheral blood mononuclear cells (PBMCs)
Immunogen
Recombinant human CD4 protein fragment (around aa 245-392) (exact sequence is proprietary)
Alternate Names
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; p55; T cell antigen T4/LEU3; T cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Database Links

Entrez Gene ID
920
SwissProt
P01730

Additional Information

Clone
CD4/1604
Chromosome Location
12p13.31
Mol. Weight of Antigen
55kDa

Related Antibodies

View All CD4 Antibodies

Functions

  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
  • (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).

Key References

  • Garcia-Herrera A, et al. Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome. J Clin Oncol. 2008; 26:3364-71.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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