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CD41a / Integrin-b (Platelet Marker) Antibody [ITGA2B/1036]

In Stock
Catalog Number Formulation Size Price
3674-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3674-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3674-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified CD41a Mouse Monoclonal Antibody (ITGA2B/1036). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified CD41a Mouse Monoclonal Antibody (ITGA2B/1036). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

Reacts with a calcium-dependent complex of CD41/CD61, a dimer of 90kDa and 140kDa present on the membrane of normal platelets and megakaryocytes. CD41/CD61 is also known as platelet glycoprotein GPIIb/GPIIIa or integrin IIa/ 3. This complex is the receptor of fibrinogen, fibronectin and von Willebrand factor, and mediates platelet adhesion and aggregation.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Research Areas
Autophagy, Cardiovascular, Developmental Biology, AKT Signaling, Articular Cartilage Extracellular Matrix, Complement System, Hematopoietic Stem Cells, Infectious Disease, Lung Cancer, Signal Transduction, Transcription Factors
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane
Gene Name
ITGA2B
Positive Control
HEL cells and human platelets in lymph nodes or tonsils., Kg1a
Immunogen
Recombinant full-length human Integrin alpha IIb protein
Alternate Names
Integrin alpha-IIb, GPalpha IIb, Platelet membrane glycoprotein IIb, BDPLT16; BDPLT2; GPalpha IIb; GT; HPA3; Integrin alpha IIb; ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex

Database Links

Entrez Gene ID
3674
SwissProt
P08514

Additional Information

Clone
ITGA2B/1036
Chromosome Location
17q21.32
Mol. Weight of Antigen
~90kDa

Related Antibodies

View All ITGA2B Antibodies

Functions

  • Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Key References

  • Schlossman S. et al. (eds) Leukocyte Typing V, Oxford University Press, Oxford, 1995.
  • Smith JW et al. Interaction of integrins v3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites. J Biol Chem 1990, 265(21):12267-12271.
  • McMichael AJ et al. (eds) Leukocyte Typing III, Oxford University Press, Oxford, 1987.
  • Du XP et al. Ligands activate integrin IIb/3 (platelet GPIIb-IIIa). Cell 1991, 65(3):409-416.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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