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CD46 (Membrane Cofactor Protein) Antibody [122.2]

In Stock
Catalog Number Formulation Size Price
4179-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4179-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4179-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Acrosome inner membrane, Cytoplasmic vesicle, Secretory vesicle
Gene Name
Positive Control
HeLa, K-562 or MOLT-4 cells. Kidney.
Immunogen
Recombinant human CD46 protein
Alternate Names
Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, AHUS2; CD46 antigen complement regulatory protein; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
122.2
Chromosome Location
1q32.2
Mol. Weight of Antigen
56-66kDa

Functions

  • Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
  • (Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
  • (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3.
  • (Microbial infection) Acts as a receptor for cultured Measles virus.
  • (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.
  • (Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed:7708671, PubMed:9379894, PubMed:11260136, PubMed:11971006).

Key References

  • Iwata, K., et al. 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J. Biol. Chem. 270: 15148-15152.
  • Liszewski, M.K., et al. 1996. Control of the complement system. Adv. Immunol. 61: 201-283.
  • Liszewski, M.K., et al. 1996. Membrane cofactor protein (MCP, CD46). Isoforms differ in protection against the classical pathway of complement. J. Immunol. 156: 4415-4421

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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