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Flow cytometry analysis of bead-bound exosomes derived from MCF-7 cells. Unstained exosomes (gray); exosomes stained with CF568-labeled CD63 Mouse Monoclonal Antibody (LAMP3/4949) (orange).
Flow cytometric analysis using MCF-7 cells. CD63 Mouse Monoclonal Antibody (LAMP3/4949) followed by goat anti-mouse IgG-CF640 (red); unstained cells (gray).
CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
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