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Cystatin B (Marker of Epithelial Ovarian Cancer Progression) Antibody [CPTC-CSTB-3]

In Stock
Catalog Number Formulation Size Price
1476-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1476-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1476-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified Cystatin B Mouse Monoclonal Antibody (CPTC-CSTB-3). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified Cystatin B Mouse Monoclonal Antibody (CPTC-CSTB-3). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human lung stained with Cystatin B Mouse Monoclonal Antibody (CPTC-CSTB-3).

Formalin-fixed, paraffin-embedded human lung stained with Cystatin B Mouse Monoclonal Antibody (CPTC-CSTB-3).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Cystatin A (also designated STF1, STFA, stefin A or cystatin AS) and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin B and liver thiol proteinase inhibitor) are thiol protease inhibitors that form complexes with papain and the cathepsins B, H, and L. cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. cystatin B protects against intracellular proteases leaking out of lysosomes and is primarily expressed in heart, liver and kidney.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
CSTB
Positive Control
HEK293T or U-87 MG cells. Human tonsil.
Immunogen
Recombinant full-length human Cystatin B protein
Alternate Names
Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CHROW21; CPI-B; CST 6; CSTB; CYTB; Stefin B; EPM1; Liver thiol proteinase inhibitor; PME; STFB; ULD

Database Links

Entrez Gene ID
1476
SwissProt
P04080

Additional Information

Clone
CPTC-CSTB-3
Chromosome Location
21q22.3
Mol. Weight of Antigen
12kDa

Related Antibodies

View All CSTB Antibodies

Functions

  • This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.

Key References

  • Wang X, et al. Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF- signaling pathway. Int J Oncol. 2014 Apr;44(4):1099-106.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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