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Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody [KRTH/1076]

In Stock
Catalog Number Formulation Size Price
MSM9-1076-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MSM9-1076-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MSM9-1076-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

Formalin-fixed, paraffin-embedded Rat Stomach stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

Formalin-fixed, paraffin-embedded Rat Stomach stained with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

Formalin-fixed, paraffin-embedded Rat Oviduct with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

Formalin-fixed, paraffin-embedded Rat Oviduct with Cytokeratin, HMW Monoclonal Antibody (KRTH/1076).

SDS-PAGE Analysis of Purified Cytokeratin, HMW MAb (KRTH/1076). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified Cytokeratin, HMW MAb (KRTH/1076). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40kDa. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human, Rat
Research Areas
Autophagy, Developmental Biology
Isotype / Light Chain
IgG1 / Kappa
Gene Name
KRT76
Positive Control
Adenocarcinomas., Skin
Immunogen
Recombinant human KRT76 protein
Alternate Names
Keratin, type II cytoskeletal 2 oral, Cytokeratin-2P, Keratin-76, Type-II keratin Kb9

Database Links

Entrez Gene ID
51350
SwissProt
Q01546

Additional Information

Clone
KRTH/1076
Chromosome Location
12q13.13
Mol. Weight of Antigen
67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8)

Related Antibodies

View All KRT76 Antibodies

Functions

  • Probably contributes to terminal cornification.

Key References

  • Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8.
  • Tseng SCG et. al. Cell 1982; 30361.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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