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Immunofluorescence Analysis of PFA-fixed HeLa cells stained using ETS2 Mouse Monoclonal Antibody (PCRP-ETS2-1D9)
followed by goat anti-mouse IgG-CF488 (green). CF640A phalloidin (red).
Flow cytometric analysis of PFA-fixed HeLa cells. ETS2 Mouse Monoclonal Antibody (PCRP-ETS2-1D9) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).
SDS-PAGE Analysis of Purified ETS2 Mouse Monoclonal Antibody (PCRP-ETS2-1D9). Confirmation of Purity and Integrity of Antibody.
ETS2 (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. ETS2 was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. ETS2 protein expression is complex and changes throughout development. ETS2 appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.
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