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Ezrin / p81 Antibody [CPTC-Ezrin-1]

In Stock
Catalog Number Formulation Size Price
7430-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7430-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7430-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Western Blot (WB)
2-4ug/ml

Summary

Ezrin, Moesin and Radixin belong to a family of highly homologous actin-associated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are co-expressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation. Overexpression of Ezrin predicts the poor prognosis of gastric adenocarcinoma.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Apical cell membrane, Cell cortex, Cell projection, Cytoplasm, Cytoskeleton, Microvillus, Microvillus membrane, Ruffle membrane
Gene Name
EZR
Positive Control
A431, HEK293, HeLa, Jurkat, MCF-7, MCF-7. Cerebral cortex and hippocampus., SKBR3
Immunogen
Recombinant human full-length Ezrin protein
Alternate Names
Ezrin, Cytovillin, Villin-2, p81, Villin-2; CVIL; Epididymis secretory protein Li 105; EZR; p81; VIL2; Cytovillin; Cytovillin 2; HEL S 105; DKFZp762H157

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CPTC-Ezrin-1
Chromosome Location
6q25.3
Mol. Weight of Antigen
87kDa

Functions

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Key References

  • Jin, Jingchun, et al. Pathology, BioMed Central, 5 Oct. 2012.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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