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Recombinant FOXL2 Antibody [FOXL2/8362R]

In Stock
Catalog Number Formulation Size Price
668-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
668-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
668-RBM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant FOXL2 Antibody

Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with FOXL2 Recombinant Rabbit Monoclonal Antibody (FOXL2/8362R). Inset: PBS instead of primary antibody; secondary only negative control.

Recombinant FOXL2 Antibody - Image 2

Formalin-fixed, paraffin-embedded human parathyroid stained with FOXL2 Recombinant Rabbit Monoclonal Antibody (FOXL2/8362R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Recombinant FOXL2 Antibody - Image 3

SDS-PAGE Analysis of Purified FOXL2 Recombinant Rabbit Monoclonal Antibody (FOXL2/8362R). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

FOXL2 is a critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. It prevents trans-differentiation of ovary to testis through transcriptional repression of the sertoli cell-promoting gene SOX9. FOXL2 is mainly expressed in ovary, parathyroid gland and sex cord-stromal tumors. FOXL2 is generally used for diagnosis of sex cord-stromal tumors with Inhibin, Calretinin and SF-1.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Endothelial Cell Marker
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus.
Gene Name
FOXL2
Positive Control
Nuclear expression in ovarian follicular and stromal cells. Granulosa cell tumor.
Immunogen
Recombinant full-length human FOXL2 protein
Alternate Names
Forkhead box protein L2, Blepharophimosis epicanthus inversus and ptosis 1; BPES 1; BPES; BPES1; Epicanthus inversus and ptosis 1; Forkhead box protein L2; Forkhead transcription factor FOXL2; PFRK; PINTO; PITUITARY FORKHEAD FACTOR; POF3

Database Links

Entrez Gene ID
668
SwissProt
P58012

Additional Information

Clone
FOXL2/8362R
Chromosome Location
3q22.3
Mol. Weight of Antigen
38kDa

Related Antibodies

View All FOXL2 Antibodies

Functions

  • Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Key References

  • Shah SP, Kobel M, Senz J, et al. Mutation of FOXL2 in granulosa-cell tumors of the ovary.N Engl J Med. 2009;360(26):2719-2729. doi:10.1056/NEJMoa0902542.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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