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Recombinant FOXP1 (Transcription Factor) Antibody [FOXP1/9381R]

In Stock
Catalog Number Formulation Size Price
27086-RBM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
27086-RBM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
27086-RBM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with FOXP1 Recombinant Rabbit Monoclonal Antibody (FOXP1/9381R). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with FOXP1 Recombinant Rabbit Monoclonal Antibody (FOXP1/9381R). Inset: PBS instead of primary antibody; secondary only negative control.

SDS-PAGE Analysis of Purified FOXP1 Recombinant Rabbit Monoclonal Antibody (FOXP1/9381R). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified FOXP1 Recombinant Rabbit Monoclonal Antibody (FOXP1/9381R). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development. FOXP1 protein plays an important role in the specification and differentiation of lung epithelium, also acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program. FOXP1 is useful in subclassification of DLBCL and a high cutoff ( � �80%) for FOXP1 is needed to achieve high specificity for the ABC subtype.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Developmental Biology, B Cell Markers, Nuclear Marker
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus.
Gene Name
FOXP1
Positive Control
Human tonsil or colon.
Immunogen
Recombinant fragment (around aa350-450) of human FOXP1 protein (exact sequence is proprietary)
Alternate Names
Forkhead box protein P1, Mac-1-regulated forkhead, Fork head related protein like B; Forkhead box protein P1 (FOXP1); Glutamine rich factor 1; hFKH1B; HSPC215; QRF1

Database Links

Entrez Gene ID
27086
SwissProt
Q9H334

Additional Information

Clone
FOXP1/9381R
Chromosome Location
3p13
Mol. Weight of Antigen
75kDa

Related Antibodies

View All FOXP1 Antibodies

Functions

  • Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735).
  • Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).

Key References

  • Rodenas-Cuadrado PM, et al. J Comp Neurol 526:1235-1266.
  • Louis, Sam Titus ASC, et al. J Neurosci 37:6575-6587.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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