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GIRK2 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody [KCNJ6/7558]

In Stock
Catalog Number Formulation Size Price
3763-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3763-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3763-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
GIRK2 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody

Formalin-fixed, paraffin-embedded human pancreas stained with GIRK2 Mouse Monoclonal Antibody (KCNJ6/7558) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control.

GIRK2 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - Image 2

Formalin-fixed, paraffin-embedded human pancreas stained with GIRK2 Mouse Monoclonal Antibody (KCNJ6/7558) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Neuroscience
Isotype / Light Chain
IgG2 / Kappa
Cellular Localization
Membrane.
Gene Name
KCNJ6
Positive Control
Human brain or pancreas.
Immunogen
Recombinant fragment of human KCNJ6 protein (exact sequence is proprietary)
Alternate Names
G protein-activated inward rectifier potassium channel 2, BIR1, Inward rectifier K(+) channel Kir3.2, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6, inwardly rectifying subfamily J member 6; BIR1; G protein activated inward rectifier potassium channel 2; GIRK2; hiGIRK2; Inward rectifier K(+) channel Kir3.2; Inward rectifier potassium channel KIR3.2; KATP2; KCNJ6; Kcnj7; KIR3.2; KPLBS; Potassium inwardly rectifying channel subfamily J member 6; Potassium voltage gated channel subfamily J member 6

Database Links

Entrez Gene ID
3763
SwissProt
P48051Human

Additional Information

Clone
KCNJ6/7558
Chromosome Location
21q22.13
Mol. Weight of Antigen
48kDa

Related Antibodies

View All KCNJ6 Antibodies

Functions

  • This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Key References

  • Schein JC, Hunter DD, Roffler-Tarlov S. Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver.Dev Biol. 1998;204(2):432-450. doi:10.1006/dbio.1998.9076

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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