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Recombinant GLUT-1 (Tumor Progression and Mesothelioma Marker) Antibody [rGLUT1/2476]

In Stock
Catalog Number Formulation Size Price
6513-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6513-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6513-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified GLUT-1 Recombinant Mouse Monoclonal Antibody (rGLUT1/2476). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified GLUT-1 Recombinant Mouse Monoclonal Antibody (rGLUT1/2476). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human Bladder stained with GLUT-1 Mouse Monoclonal Antibody (rGLUT1/2476).

Formalin-fixed, paraffin-embedded human Bladder stained with GLUT-1 Mouse Monoclonal Antibody (rGLUT1/2476).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 55kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative).

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
ELISA, Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Colon Cancer, Endothelial Cell Marker, Infectious Disease, Neural Stem Cells, Neuroinflammation
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Melanosome, Photoreceptor inner segment
Gene Name
SLC2A1
Positive Control
A431, colon and ovarian carcinoma., K562, MDA-MB-231 cells or erythrocytes. Mesothelioma or breast
Immunogen
Recombinant fragment of human GLUT1 protein (around aa 203-305) (exact sequence is proprietary)
Alternate Names
Solute carrier family 2, facilitated glucose transporter member 1, Glucose transporter type 1, erythrocyte/brain, HepG2 glucose transporter, Erythrocyte/hepatoma glucose transporter; Glucose transporter type-1; GLUT1; GLUT1DS; GLUTB; GT1; GTG1; Gtg3; HepG2 glucose transporter; PED; RATGTG1; Solute carrier family 2; Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Database Links

Entrez Gene ID
6513
SwissProt
P11166

Additional Information

Clone
rGLUT1/2476
Chromosome Location
1p34.2
Mol. Weight of Antigen
55kDa

Related Antibodies

View All SLC2A1 Antibodies

Functions

  • Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).

Key References

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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