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GLUT-1 (Tumor Progression and Mesothelioma Marker) Antibody [GLUT1/7308]

In Stock
Catalog Number Formulation Size Price
6513-MSM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
6513-MSM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
6513-MSM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human esophagus stained with GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Inset: PBS instead of primary antibody; secondary only negative control.

Formalin-fixed, paraffin-embedded human esophagus stained with GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Inset: PBS instead of primary antibody; secondary only negative control.

SDS-PAGE Analysis of Purified GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified GLUT-1 Mouse Monoclonal Antibody (GLUT1/7308). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Recognizes a protein of 55kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative).

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Colon Cancer, Endothelial Cell Marker, Infectious Disease, Neural Stem Cells, Neuroinflammation
Isotype / Light Chain
IgG /
Cellular Localization
Cell surface
Gene Name
SLC2A1
Positive Control
A431|colon and ovarian carcinoma.|K562|MDA-MB-231 cells or erythrocytes. Mesothelioma or breast
Immunogen
Recombinant fragment of human GLUT1 protein (around aa 200-400) (exact sequence is proprietary)
Alternate Names
Solute carrier family 2, facilitated glucose transporter member 1, Glucose transporter type 1, erythrocyte/brain, HepG2 glucose transporter, Erythrocyte/hepatoma glucose transporter; Glucose transporter type-1; GLUT1; GLUT1DS; GLUTB; GT1; GTG1; Gtg3; HepG2 glucose transporter; PED; RATGTG1; Solute carrier family 2; Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Database Links

Entrez Gene ID
6513
SwissProt
P11166

Additional Information

Clone
GLUT1/7308
Chromosome Location
1p34.2
Mol. Weight of Antigen
55kDa

Related Antibodies

View All SLC2A1 Antibodies

Functions

  • Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).

Key References

  • Shuang Cao,et al. GLUT1 biological function and inhibition: research advances. Future Medicinal Chemistry202113:14,1227-1243

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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