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IL-4 (Interleukin-4), Mouse Antibody [11B11]

In Stock
Catalog Number Formulation Size Price
RTM1-2008-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
RTM1-2008-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
RTM1-2008-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified IL-4 Rat Monoclonal Antibody (11B11). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified IL-4 Rat Monoclonal Antibody (11B11). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

Product Properties & Targets

Antibody Type
Rat Monoclonals
Host
Rat
Applications
ELISA, Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
IL4
Positive Control
Spleen, Thymus or Lymph Node.
Immunogen
Partially Purified native Mouse IL-4
Alternate Names
Interleukin-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, IGG1 induction factor, Lymphocyte stimulatory factor 1, B cell growth factor 1 (BCGF1); B cell IgG differentiation factor; B-Cell Stimulatory Factor 1 (BSF1); Binetrakin; IGG1 induction factor; IL4; Il4e12; Interleukin 4 variant 2; Interleukin 4, isoform 1; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra

Database Links

Entrez Gene ID
16189
SwissProt
P07750

Additional Information

Clone
11B11
Chromosome Location
11 B1.3; 11 31.97 cM (Mouse)
Mol. Weight of Antigen
13-14kDa

Related Antibodies

View All IL4 Antibodies

Functions

  • Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3083412). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). It enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (PubMed:25847241). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964).

Key References

  • Dzhagalov I, et al. 2007. J. Immunol. 178:2113. (ELISA)
  • Xu G, et al. 2007. J. Immunol. 179:5358. (ELISA)
  • Hara M, et al. 2001. J. Immunol. 166:3789. (Neutralization)
  • Charles N, et al. 2010. Nat. Med. 16:701. (FC)
  • Wang W, et al. 2007. J. Immunol. 178:4885. (Neutralization)
  • Openshaw P, et al. 1995. J. Exp. Med. 182:1357. (ICC)
  • Litton M, et al. 1994. J. Immunol. Methods 175:47. (IHC)
  • Zavorotinskaya T, et al. 2003. Mol. Ther. 7:155. (IP)
  • Fan WY, et al. 2001. Exp. Biol. Med. 226:1045. (IHC)

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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