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IL18R1 Antibody [IL18R1/7591]

In Stock
Catalog Number Formulation Size Price
8809-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
8809-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
8809-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified IL18R1 Mouse Monoclonal Antibody (IL18R1/7591). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified IL18R1 Mouse Monoclonal Antibody (IL18R1/7591). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human adrenal gland stained with IL18R1 Mouse Monoclonal Antibody (IL18R1/7591). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Formalin-fixed, paraffin-embedded human adrenal gland stained with IL18R1 Mouse Monoclonal Antibody (IL18R1/7591). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-Î � production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin s disease cell lines, and does not bind IL-1α or IL-1β. The association of IL-18 to IL-18R leads to activation of NFÎ �B. At present two subunits of IL-18R have been characterized: IL-18Rα and IL-18Rβ. IL-18Rα has been described as the ligand-binding chain and IL-18Rβ as the signal-transduction chain.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, AKT Signaling, Cytokine Signaling, Mitochondria Marker
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane.
Gene Name
IL18R1
Positive Control
Human lung|leukocytes|liver or thymus.|spleen
Immunogen
Recombinant fragment (around aa1-200) of human IL18R1 protein (exact sequence is proprietary)
Alternate Names
Interleukin-18 receptor 1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, Interleukin-18 receptor alpha, CD218 antigen-like family member A; CDw218a antigen; IL-18R1; IL-1Rrp; IL1 receptor-related protein; Il18ralpha;IL1R-rp; IL1RRP; Interleukin 18 receptor, alpha chain

Database Links

Entrez Gene ID
8809
SwissProt
Q13478

Additional Information

Clone
IL18R1/7591
Chromosome Location
2q12
Mol. Weight of Antigen
62kDa

Related Antibodies

View All IL18R1 Antibodies

Functions

  • Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

Key References

  • Torigoe, K., et al. 1997. Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem. 272: 25737-25742.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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