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IL18RAP / CD218b Antibody [IL18RAP/7771]

In Stock
Catalog Number Formulation Size Price
8807-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
8807-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
8807-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
IL18RAP / CD218b Antibody

Formalin-fixed, paraffin-embedded human adrenal gland stained with IL18RAP Mouse Monoclonal Antibody (IL18RAP/7771). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Cytokine Signaling
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane.
Gene Name
IL18RAP
Positive Control
adrenal gland or colon.|Human spleen|lung
Immunogen
Recombinant fragment (around aa200-400) of human IL18RAP protein (exact sequence is proprietary)
Alternate Names
Interleukin-18 receptor accessory protein, Accessory protein-like, CD218 antigen-like family member B, CDw218b, IL-1R accessory protein-like, Interleukin-1 receptor 7, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, IL18RAP; Accessory protein like; AcPL; CD218 antigen-like family member B; CDw218b; IL 18RAcP; IL 1R accessory protein like; IL 1R7; IL 1RAcPL; IL18R Beta; IL18RAP; IL18Rbeta; Interleukin 18 receptor accessory protein; Interleukin-1 receptor 7; Interleukin-18 receptor beta chain

Database Links

Entrez Gene ID
8807
SwissProt
O95256

Additional Information

Clone
IL18RAP/7771
Chromosome Location
2q12.1
Mol. Weight of Antigen
68kDa

Related Antibodies

View All IL18RAP Antibodies

Functions

  • Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).

Key References

  • Torigoe, K., et al. 1997. Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem. 272: 25737-25742.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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