Free Shipping in the U.S. for orders over $1000.  Shop Now>>

Insulinoma Associated 2 / INSM2 Antibody [INSM2/4291]

In Stock
Catalog Number Formulation Size Price
84684-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
84684-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
84684-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription. INSM2 may function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
Positive Control
Human pancreas tissue.
Immunogen
Recombinant fragment of human INSM2 protein (around aa 432-540) (exact sequence is proprietary)
Alternate Names
Insulinoma-associated protein 2, Zinc finger protein IA-6, IA1; Insulinoma associated protein 2 (IA2); Zinc finger protein IA6

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
INSM2/4291
Chromosome Location
14q13.2
Mol. Weight of Antigen
58kDa

Functions

  • May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Key References

  • Li, Q., et al. 1997. Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. Biochem. Biophys. Res. Commun. 236:776-781.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Reviews

There are no reviews yet.

Be the first to review “Insulinoma Associated 2 / INSM2 Antibody”

Your email address will not be published. Required fields are marked *

PARTNERSHIP OPPORTUNITIES

NeoBiotechnologies holds Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK