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Interferon gamma (IFNG) Antibody [SPM408]

In Stock
Catalog Number Formulation Size Price
3458-MSM1X-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3458-MSM1X-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3458-MSM1X-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

Interferon (IFN)- translated precursor is 166 amino acids, including the 23 amino acid secretory sequence. Multiple forms exist due to variable glycosylation and under non-denaturing conditions due to dimers and tetramers.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Research Areas
Cardiovascular, Immuno Oncology, Immunology, Colon Cancer, Complement System, Cytokine Signaling, Hematopoietic Stem Cells, Neuroinflammation, PD-1 blockade immunotherapy, Transcription Factors
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
IFNG
Positive Control
PMA stimulated human peripheral blood mononuclear cells.
Immunogen
Purified recombinant human IFN-gamma
Alternate Names
Interferon gamma, Immune interferon, AMCF1; Beta thromboglobulin like protein; CXC chemokine ligand 8 (CXCL8); Emoctakin; Granulocyte chemotactic protein 1 (GCP1); IFG; IFI; IFN Immune; IFN-gamma (IFNG); Interleukin 8; Interferon gamma; LECT; LUCT; Lymphocyte derived neutrophil activating factor; LYNAP; Macrophage Activating Factor (MAF); Monocyte derived neutrophil activating protein (MONAP); Monocyte derived neutrophil chemotactic factor (MDNCF); Neutrophil activating factor (NAF); Neutrophil activating peptide 1 (NAP1); Neutrophil activating protein 1 (NAP1); SCYB8; T cell chemotactic factor; T Cell Interferon; Type II Interferon

Database Links

Entrez Gene ID
3458
SwissProt
P01579

Additional Information

Clone
SPM408
Chromosome Location
12q14
Mol. Weight of Antigen
20-25kDa

Related Antibodies

View All IFNG Antibodies

Functions

  • Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed:8666937). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation (PubMed:8349687). Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription (PubMed:16914093). Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits (PubMed:8666937). In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading (PubMed:8163024). Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference (PubMed:11112687). Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (PubMed:7729559). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).

Key References

  • Farrar MA and Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 1993, 11:571-611
  • Vilcek J. Forty years of interferon, forty years of cytokines. Cytokine Growth Factor Rev 1997,8(4):239
  • Vilcek J et al. Induction of human interferon gamma with phorbol esters and phytohemagglutinin. Methods Enzymol 1986,119:48-54

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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